Decreased renal function does not alter the single-dose pharmacokinetics of metronidazole. ) Unnecessary use of the drug should be avoided. Metronidazole Half-Life – How Long Does it Stay in Your. [51] The biological activity of hydroxymetronidazole is 30% to 65%, and the elimination half-life is longer than that of the parent compound. The liver breaks down metronidazole into five components, or metabolites Per the prescribing information, the half life (time for 50% of the drug to be metabolized) is about 8 hours. This drug may be detectable in your system for up to 44 hours, lower respiratory tract, Metronidazole has been shown to be carcinogenic in mice and rats (see , doctor, A general rule of thumb is that it takes about 5 half lives for a drug to be considered completely. How long does metronidazole stay in your system? Its use should be reserved for the con-ditions described in the Indications and Usage section below. Metronidazole has been shown to be carcino-genic in mice and rats. P04010-1 818 930 001 Flagyl® metronidazole tablets Flagyl® metronidazole tablets. 1 mL/min) and who received a single intravenous infusion of metronidazole 500 mg had no significant. Subjects with end-stage renal disease (ESRD; CL CR= 8. Halflife = 6-8 hours: The average elimination half-life of Metronidazole is reported as 6-7 hours in some studies, but is more commonly reported as 7-8 hours. However, pharmacokinetic data demonstrate that the half-life of metronidazole is 8-12 h and blood levels at 12 h exceed the in vitrominimum inhibitory concentration (MIC) for most anaerobic infections PRECAUTIONS. A general rule of thumb is that it takes about 5 half lives for a drug to be considered completely metabolized. The elimination half-life, measured during the first 3 days of life, was inversely related to gestational age. The half-life can be affected by age, kidney insufficiency, and/or liver damage. In infants whose gestational ages were between 28 and 40 weeks, the corresponding elimination half-lives ranged from 109 to 22. Therefore, it should take about 2 to 3 days for metronidazole to be completely eliminated from the body Patients receiving phenobarbital or phenytoin metabolise metronidazole at a much greater rate than normally, reducing the half-life to approximately 3 hours. Metronidazole reduces the clearance of 5-fluorouracil and can therefore result in increased toxicity of 5-fluorouracil elimination half-life of metronidazole in healthy subjects is eight hours. Traditional metronidazole dosing regimens utilize an every 8 h dosing strategy to treat anaerobic and mixed anaerobic infections. [2] [3] The biological half-life of metronidazole in healthy adults is eight hours, in infants during the first two months of their lives about 23 hours, and in premature babies up to 100 hours.
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